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John O Holloszy Selected Research

Insulin (Novolin)

1/20192 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.
2/2014Multiple dietary supplements do not affect metabolic and cardio-vascular health.
4/2013"Deficiency" of mitochondria in muscle does not cause insulin resistance.
11/2012Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.
2/2012Bayesian functional integral method for inferring continuous data from discrete measurements.
5/2011Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.
3/2010Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production.
7/2009Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus.
7/2009Is "fat-induced" muscle insulin resistance rapidly reversible?
1/2009Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance.
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John O Holloszy Research Topics

Disease

30Insulin Resistance
01/2019 - 01/2002
7Weight Loss (Weight Reduction)
07/2009 - 07/2005
5Type 2 Diabetes Mellitus (MODY)
04/2013 - 01/2009
4Inflammation (Inflammations)
01/2016 - 08/2007
4Hypoxia (Hypoxemia)
11/2012 - 01/2002
3Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2019 - 11/2004
3Glucose Intolerance
05/2011 - 02/2005
3Neoplasms (Cancer)
04/2010 - 12/2006
3Body Weight (Weight, Body)
10/2008 - 03/2005
2Frailty
11/2005 - 12/2002
2Obesity
07/2005 - 02/2005
1Hypersensitivity (Allergy)
01/2016
1Infections
01/2016
1Iron Deficiencies
05/2011
1Overweight
05/2011
1Chronic Disease (Chronic Diseases)
04/2010
1Malnutrition (Nutritional Deficiencies)
10/2008
1Coronary Disease (Coronary Heart Disease)
01/2005
1Abdominal Obesity
11/2004
1Atherosclerosis
04/2004
1Mitochondrial Diseases (Mitochondrial Disease)
03/2004
1Hypertension (High Blood Pressure)
06/2002

Drug/Important Bio-Agent (IBA)

23Insulin (Novolin)FDA Link
01/2019 - 01/2002
21Glucose (Dextrose)FDA LinkGeneric
01/2019 - 01/2002
7Proteins (Proteins, Gene)FDA Link
01/2016 - 01/2002
5LipidsIBA
01/2019 - 03/2004
4Fatty Acids (Saturated Fatty Acids)IBA
05/2011 - 02/2005
3Insulin-Like Growth Factor I (IGF-1)IBA
02/2014 - 10/2008
2C-Reactive ProteinIBA
01/2019 - 08/2007
2ginsenoside ReIBA
11/2012 - 05/2011
2Dehydroepiandrosterone (DHEA)IBA
05/2011 - 11/2004
2Triiodothyronine (Liothyronine)FDA LinkGeneric
03/2010 - 08/2007
1Hydrocortisone (Cortisol)FDA LinkGeneric
01/2016
1Molecular Chaperones (Chaperone, Molecular)IBA
01/2016
1VaccinesIBA
01/2016
1Biomarkers (Surrogate Marker)IBA
02/2014
1C-PeptideIBA
02/2012
1Citrate (si)-Synthase (Synthase, Citrate)IBA
05/2011
1EnzymesIBA
05/2011
1Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)IBA
05/2011
1Citric Acid (Citrate)FDA LinkGeneric
05/2011
1IronIBA
05/2011
1Oleic Acid (Oleate)IBA
05/2011
1CytokinesIBA
05/2011
1Gonadal Steroid Hormones (Sex Hormones)IBA
04/2010
1Testosterone (Sustanon)FDA Link
03/2010
1AdiponectinIBA
03/2010
1Triglycerides (Triacylglycerol)IBA
07/2009
1Heparin (Liquaemin)FDA LinkGeneric
07/2009
1Nonesterified Fatty Acids (NEFA)IBA
07/2009
1Insulin-Like Growth Factor Binding Protein 3IBA
10/2008
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2007
1Interleukin-6 (Interleukin 6)IBA
06/2007
1Anabolic AgentsIBA
02/2007
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2006
1Hormones (Hormone)IBA
12/2006
1AMP-Activated Protein KinasesIBA
07/2005
1p38 Mitogen-Activated Protein KinasesIBA
07/2005
1Dantrolene (Dantrium)FDA LinkGeneric
06/2005
1KN 93IBA
06/2005
1AnisomycinIBA
04/2005
14- (4- fluorophenyl)- 2- (4- hydroxyphenyl)- 5- (4- pyridyl)imidazoleIBA
04/2005
1Calcineurin InhibitorsIBA
03/2005
1Cyclosporine (Ciclosporin)FDA LinkGeneric
03/2005
1PPAR alphaIBA
02/2005
1Lipoproteins (Lipoprotein)IBA
01/2005
1Protein Kinase CIBA
08/2004
1Protein Isoforms (Isoforms)IBA
08/2004
1calpastatinIBA
05/2004
1Dactinomycin (Actinomycin)FDA LinkGeneric
12/2003
1Glucosamine (Dona)IBA
12/2003
1Uridine Diphosphate (UDP)IBA
12/2003
1Oxygen (Dioxygen)IBA
12/2002
1Uncoupling Protein 1IBA
06/2002
1Cycloheximide (Cicloheximide)IBA
01/2002
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2002
1AICA ribonucleotide (ZMP)IBA
01/2002
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2002

Therapy/Procedure

5Caloric Restriction
03/2008 - 04/2004
2Activities of Daily Living (ADL)
11/2005 - 12/2002
1Therapeutics
05/2011